аЯрЁБс>ўџ ')ўџџџ&џџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџьЅС` №ПюbjbjЫsЫs .ЉЉю џџџџџџЄммммммм№дддд р №з ЖјјјјјгггV X X X X X X $ hѕ Ь| мРггРР| ммјјл‘    Р^мјмјV  РV   мм јь рЪq__Шд  V Ї 0з  С (ФС  С м Tг"ѕ !Ÿггг| | ьгггз РРРР№№№фд№№№д№№№ммммммџџџџ PHYSICAL ACTIVITY IN LEISURE TIME IS ASSOCIATED WITH SLOWER AGEING People who exercise more in their free time appear to be biologically younger than their more sedentary counterparts, suggests a study to be published shortly in Archives of Internal Medicine. Physical activity has already been shown to have a major impact on health; frequent exercisers display reduced cardiovascular risk and are at lower risk for type 2 diabetes, mellitus, cancer, hypertension, obesity and osteoporosis. However, despite the known benefits of physical activity, inactivity continues to be a major public health problem, increasing the propensity to aging-related diseases and death. This study suggests that a sedentary lifestyle may diminish life expectancy not only by predisposing to aging-related diseases but also because it may influence the ageing process itself. Professor Tim Spector, Dr Lynn Cherkas (King’s College London) and Professor Abraham Aviv in New Jersey, looked for evidence of ageing at a molecular level in the population by analysing telomeres, which cap the end of chromosomes in our cells and protect them from damage. With age, our telomeres shorten, leaving us more susceptible to cell damage, which causes disease. However, there is considerable variation between people and recent research has already highlighted several lifestyle factors (eg. smoking, obesity,) that are associated with shorter than average telomeres. The investigators recruited 2401 volunteers from the UK aged 18-81years onto the study. All completed questionnaires detailing their levels of physical activity during leisure time in the last 12 months, in addition to a wide range of health and lifestyle issues. The investigators found that telomere length decreased steadily with age and there was a significant association between increasing physical activity and longer telomere length even after adjusting for other measurable influences (body mass index (BMI), smoking, socioeconomic status (SES)). Dr Lynn Cherkas explains “Overall, the difference in telomere length between the most active subjects and the inactive subjects corresponds to around 9 years of ageing.” The study population was comprised of MZ and DZ twins. Comparing the telomere lengths of twins who were raised together but take different amounts of exercise reduces the effect of genetic and environmental variation and so provides a more powerful test of the hypothesis. This design revealed that on average, the telomeres of the more active twin were significantly longer that those of the less active twin, confirming previous results. Professor Spector states “Our study, performed on a large cohort, indicates that differences in telomere length between active and inactive individuals cannot be explained by variations in genes, smoking, BMI and SES. A sedentary lifestyle appears to have an effect on telomere dynamics – thus providing a powerful message that could be used by clinicians to promote the potentially anti-aging effect of regular exercise.” "5<DELq‹“šЙч   R   b Ё Ѕ y z ‹  Ѓ Ј П [ _ o p Щ й э я !"Зц0QhНОзийпрŠ+йх"&CОд!UeьюќјќјёјэјэјэјэјэјщјщјщјхсјсјсјсјнјйјйјйхйјејйейејебјбјЭЦјејејејЭјбјбјбјбј hžWGhžWGhžWGhOWhh‰ih;Ѓh{^YhЊ.­hџ|Ыht&Рh9~{ hЙFї5\hЙFїhO“HDE  c d Ќ ­ прŠ‹EFю§јііііііііііііі$a$юў,1hА‚. АЦA!А"А# $ %ААФАФ Ф†œ@@ёџ@ NormalCJ_HaJmH sH tH DAђџЁD Default Paragraph FontViѓџГV  Table Normal :V і4ж4ж laі (kєџС(No List 2>@ђ2 Title$a$5\ю џџџџDEcdЌ­прŠ‹E F № ˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€ю ю ю №8№@ёџџџ€€€ї№’№№0№( № №№B №S №ПЫџ ?№џџ"Kн<-##KнЉ‰тт№ фф№ 9*€urn:schemas-microsoft-com:office:smarttags€place€B*€urn:schemas-microsoft-com:office:smarttags€country-region€ .ЂryƒŠ[]шя< C F O P W № № yzop!"Одззийо‰Њ Њ & C F F ` `   ! U e ь э № < C № х‰i7t žWG{^Ynd_%`OWh9~{O“;ЃЊ.­ЊДt&Рџ|ЫЙFїџ@€|Я+ю `@џџUnknownџџџџџџџџџџџџG‡z €џTimes New Roman5€Symbol3& ‡z €џArial"1ˆ№аhЂЫСІЂЫСІЧ' Ч'  № ДДr4ш ш 2ƒ№мHP)№џ?фџџџџџџџџџџџџџџџџџџџџџO“2џџ3SOCIAL STATUS IS ASSOCIATED WITH THE AGEING PROCESSLynn Francine Cherkas Full Nameўџр…ŸђљOhЋ‘+'Гй0А˜др , @L l x „˜ Јф4SOCIAL STATUS IS ASSOCIATED WITH THE AGEING PROCESSLynn Francine Cherkas Normal.dot Full Name2Microsoft Office Word@Œ†G@М S__Ш@М S__ШЧ' ўџеЭеœ.“—+,љЎ0< hpœЄЌД МФЬд м ф$Guy's & St. Thomas' Hospital Trustш Ј 4SOCIAL STATUS IS ASSOCIATED WITH THE AGEING PROCESS Title ўџџџўџџџўџџџ !"#$%ўџџџ§џџџ(ўџџџўџџџўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџRoot Entryџџџџџџџџ РFpѕєq__Ш*€1TableџџџџџџџџWordDocumentџџџџџџџџ.SummaryInformation(џџџџDocumentSummaryInformation8џџџџџџџџџџџџCompObjџџџџџџџџџџџџqџџџџџџџџџџџџџџџџџџџџџџџџўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџўџ џџџџ РFMicrosoft Office Word Document MSWordDocWord.Document.8є9Вq