ࡱ> 7 KbjbjUU "7|7|Kl.......B```` lBV2: $ f.   .. ..  !..  _wB`c $&0Vs ^ BB.... PRESS RELEASE Issue date: Wednesday, November 24 2004 EMBARGOED FOR PUBLICATION UNTIL 11.30AM, WEDNESDAY NOVEMBER 24 Blame your genes for a restless nights sleep new research revealed New research carried out by doctors in the Twin Research Unit at St Thomas Hospital, London, indicates that genetic factors make a substantial contribution to common sleep disorders. Professor Tim Spector, Director of the Unit, revealed the results of a new study of almost 2,000 pairs of female twins during a press briefing at the Science Media Centre today (Wednesday, November 24). The full research study will be published in the December edition of scientific journal Twin Research. 1,937 pairs of identical and non-identical twins from the Twin Research Unit database were asked questions on sleep disorders such as obstructive sleep apnoea (OSA) and restless legs syndrome (RLS). Dr Adrian Williams, a co-author of the research study and Consultant in the Sleep Disorders Centre at St Thomas Hospital, says: Sleep disorders are surprisingly common and it is increasingly recognised that they can have a devastating impact on sufferers everyday lives they are no laughing matter. For example, OSA affects approximately 24% of men and 9% of women aged 30 to 60. It even contributes to road traffic accidents when sufferers fall asleep at the wheel. Twins were asked, in connection with OSA, if they ever snored and, if so, how often their snoring disturbed others or caused them to wake up they were also asked if they experienced daytime sleepiness. In relation to RLS, twins were asked if they ever experienced an urge to move their legs during the night to relieve tingling or numbness and also if they ever found their legs jerked involuntarily during the night. Key findings of the research study include: Genes contribute significantly to sleep disorders approximately 50% of the variance in liability to these symptoms is due to genetic factors. Heritability was estimated to be 42% (disruptive snoring), 45% (daytime sleepiness), 54% (restless legs) and 60% (legs jerking). An important strength of the research study is that these heritability estimates have been corrected to take into account other influences on the symptoms of snoring and daytime sleepiness such as sufferers being overweight or heavy smokers. Professor Spector says: These results suggest a substantial genetic contribution to the symptoms of both obstructive sleep apnoea and restless legs syndrome and that could be good news for people who suffer from these conditions if the genes responsible can be identified. One reason the genes for disruptive sleep may have persisted is that poor sleep patterns make people gain weight and retain fat. These genes may have helped our ancestors through periods of famine and the Ice Age. The Twin Research Unit was originally set up at St Thomas Hospital in 1992 to look at the role that genes play in the development of rheumatic diseases in older women and has now expanded to lok at most common diseases, behaviours and traits. If you are a twin (identical or non-identical) aged over 15 who would like to volunteer to join the 10,000 twins on the register of the Twin Research Unit at St Thomas Hospital, please call 020 7188 5555. - ends - Note to editors: Contact: Matt Akid, Communications Manager, Guys and St Thomas NHS Foundation Trust tel: 020 7188 5577/07961 434247 or e-mail:  HYPERLINK "mailto:matthew.akid@gstt.sthames.nhs.uk" matthew.akid@gstt.sthames.nhs.uk - out of hours, please call the hospital switchboard on 020 7188 7188 and ask for the site nurse practitioner. Claire Bithell, Science Information Officer, Science Media Centre tel: 020 7670 2976 or email:  HYPERLINK "mailto:CBithell@ri.ac.uk" CBithell@ri.ac.uk Guys and St Thomas provides million patient contacts in acute and specialist hospital services every year. As one of the biggest NHS Trusts in the UK, it employs over 8,000 staff. The Trust also works in partnership with the Schools of Medicine, Dentistry, Nursing and Biomedical Sciences of Kings College London and other Higher Education Institutes to deliver high quality education and research. Website:  HYPERLINK "http://www.guysandstthomas.nhs.uk" www.guysandstthomas.nhs.uk 3. The research paper Genetic Influences in Self-Reported Symptoms of Obstructive Sleep Apnoea and Restless Legs: A Twin Study will be published in the December edition of Twin Research (Vol. 7, No. 6). A copy of the full research paper is available from Matt Akid or Claire Bithell. 4. Contact Claire Bithell on Wednesday, November 24 until 5.30pm and then Matt Akid after that time. 5. Professor Tim Spector is author of the recent popular science book Your Genes Unzipped: How Your Genetic Inheritance Shapes Your Life (Robson Books 2003, 8.99). AB[\yzKͿݵͿݫ͡ݝ6h0J>*B*hphjUhjUh0JhjޤUh jUh\h 5\hh5h6]55^J^J6>* 5>*CJ jU*ABPQ\ ] ) *   / dh &dP$a$$]a$K/ 0 A 3 4 FG K; & Fe^e` & F$a$ & Fdhdh;#$p>?BDEFGHIJKh^h. 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