ࡱ> @ bjbjFF *,,bJJJJfb-2L%-'-'-'-'-'-'-$.R*1K-```K-`-`^%-`%-)*, 9 JRE+",Lv-0-g+1R1D, 4@"1,T;%K-K-bb$ b.bb  PRESS RELEASE Issue date: Social status proven to be direct link to the ageing process People of lower socio-economic status appear to be biologically older than those in higher socio-economic groups, suggests a study led by Professor Tim Spector from the Twin Research Unit at Guys and St Thomas NHS Foundation Trust. Socio-economic status has already been shown to have a major impact on health, with much evidence that lower socio-economic status is associated with increased risks of cardiovascular, respiratory, rheumatic and psychiatric diseases. The study, published today in journal Aging Cell, suggests that lower socio-economic status is not only linked to age-related diseases, but also influences the actual aging process itself. Professor Spector and colleagues in London and New Jersey looked for evidence of aging at a molecular level in the population by analysing telomeres, which cap the end of chromosomes in our cells and protect them from damage. With age, our telomeres shorten, leaving us more susceptible to cell damage and cell death. The investigators recruited 1,552 women from the UK aged 18-75 years onto the study. All were assigned to one of five socio-economic groups based on the National Statistics Socio-Economic Classification (NS-SEC, 2002). The investigators found that telomere length decreased steadily with age and that the telomeres of the women in the lower socio-economic groups were significantly shorter than those in higher socio-economic groups even after adjusting for other measurable influences (body mass index (BMI), smoking, exercise). In addition, this trend could not be explained by education or income differences. Greater exposure to adverse psychosocial environments and increased psychological stress are possible contributors to the observed reduction in telomere length with lower socio-economic status. The average difference in telomere length between manual and non-manual workers was equivalent to an extra seven years of telomere loss. The study population was comprised of identical (MZ) and non-identical (DZ) twins. Comparing the telomere lengths of twins who were raised together and started life in the same socio-economic status, but are currently in different socio-economic groups, reduces the effect of genetic and environmental variation and so provides a powerful research tool. This design revealed that on average, the telomeres of the higher socio-economic status twin were significantly longer that those of their lower socio-economic status twin. Professor Spector commented: Our study, performed on a large cohort, indicates that the clear differences in telomere length between low and high socio-economic status individuals cannot be explained by variations in genes, smoking, BMI and physical activity. Rather, socio-economic status appears to have an impact on telomere dynamics. The mechanisms for this are speculative but could be related to exposure to environments that produce extra oxidative stress such as poor diet or could simply be a result of the long term stress of living within a lower social status and its resultant insecurity and lack of control. Socio-economic status is not only a factor in dying early but also in how fast you age. The Twin Research Unit studies a wide variety of traits and diseases and is always on the look out for volunteers aged over 16. Please contact 020 7188 5555 or  HYPERLINK "http://www.twinsUK.ac.uk" www.twinsUK.ac.uk for more information about how to get involved. - ends - Note to editors: Contact: Communications Department at Guys and St Thomas NHS Foundation Trust. Tel: 020 7188 5577 or e-mail:  HYPERLINK "mailto:communications@gstt.nhs.uk" communications@gstt.nhs.uk Out of hours, please call the hospital switchboard on 020 7188 7188 and ask for the site nurse practitioner. Guys and St Thomas provides million patient contacts in acute and specialist hospital services every year. As one of the biggest NHS Trusts in the UK, it employs over 8,500 staff. The Trust also works in partnership with the Schools of Medicine, Dentistry, Nursing and Biomedical Sciences of Kings College London and other Higher Education Institutes to deliver high quality education and research. Website:  HYPERLINK "http://www.guysandstthomas.nhs.uk" www.guysandstthomas.nhs.uk 3 The Twin Research Unit was originally set up at St Thomas Hospital in 1992 to look at the role that genes play in the development of rheumatic diseases in older women and has now expanded to look at most common diseases, behaviours and traits. 4 Previous research by the TwinsUK registry the largest adult twin registry in the UK has included studies on common traits and diseases, ranging from cataracts, blood clotting and musical ability. To find out more, or if you are a twin interested in joining the register, please visit:  HYPERLINK "http://www.twin-research.ac.uk" www.twin-research.ac.uk !"#`m  I J N : C E O T X ` j s t  4 N  ; < = Z [ b R]Sh/AJW&ĴļȼȼĦĦȼȴȴȴȴȴh|nh}Ph|n6]hvh kh>6-hkh}Ph}h>6-h}5\ h}5\ hT5^J hT56>*hT55>*CJ hT5jhT5UA!"#`aN O < = r Wr r r r r r r O r r r r "r r q$r r "r r r r E(r r { dhgdCdhgd|ndhgdvdhgd}$a$gd} &dP$a$$]a$&+&6|xy *.W[^_opxyZƽxh#nhk0Jhjh#nhkUhhkhkhjhkUh hT5\hhT55\h hkh h}h hT5hhkhT5 hT55h hT5^J hC0JjޤhCUjhCUhChvh}Ph}-34!"r r r r r r r r r r r r r r r r r r r r r  0^`07$8$H$^`gdC 7$8$H$gdC & F gd@ & F gd*$a$gd}dhgdCZz !rw/<>?klmȼıh#nh}P0Jjh}PUjh}PUh}PhC h@hhT50J>*B*hphjhT5UhjhT5Uh hT5h h*hr r r r r r . 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